Reversible activation of pH-sensitive cell penetrating peptides attached to gold surfaces. Issue 2 (20th October 2014)

• Record Type: Journal Article
• Authors: Baio, Joe E.; Schach, Denise; Fuchs, Adrian V.; Schmüser, Lars; Billecke, Nils; Bubeck, Christoph; Landfester, Katharina; Bonn, Mischa; Bruns, Michael; Weiss, Clemens K.; Weidner, Tobias
• Is Part Of: Chemical communications. Volume 51:Issue 2(2015)
• Page Start: 273
• Page End: 275
• Publication Date: 2014-10-20
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c4cc07278b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Here, we demonstrate that a fusion protein mimic, designed to achieve a reversible, pH-driven helix-coil transition mechanism, retain its functionality when covalently bound to a surface. Abstract : pH-sensitive viral fusion protein mimics are widely touted as a promising route towards site-specific delivery of therapeutic compounds across lipid membranes. Here, we demonstrate that a fusion protein mimic, designed to achieve a reversible, pH-driven helix-coil transition mechanism, retains its functionality when covalently bound to a surface.