Increased prevalence of cigarette smoking in Japanese patients with sarcoidosis. Issue 7 (23rd September 2013)

• Record Type: Journal Article
• Authors: Hattori, Takeshi; Konno, Satoshi; Shijubo, Noriharu; Ohmichi, Mitsuhide; Nishimura, Masaharu
• Is Part Of: Respirology. Volume 18:Issue 7(2013)
• Page Start: 1152
• Page End: 1157
• Publication Date: 2013-09-23
• Subjects: epidemiology -- gender -- sarcoidosis -- smoking -- susceptibility; Respiratory organs -- Diseases -- Periodicals; Respiratory organs -- Periodicals; 612.2
• DOI: 10.1111/resp.12153
• Languages: English
• ISSNs: 1323-7799

Abstract

Abstract: Background and objective: Several studies have shown that individuals with sarcoidosis in Western populations are less likely to have smoked before diagnosis. Epidemiological characteristics of sarcoidosis are known to differ between Japanese and Westerners. Therefore, the relationship between cigarette smoking and sarcoidosis in a Japanese population was investigated. Methods: Three hundred eighty‐eight patients newly diagnosed with sarcoidosis between 2000 and 2008 were retrospectively identified. The results of two large surveys of smoking prevalence in Japan provided reference data. Specific clinical manifestations of sarcoidosis were compared between current smokers and never‐smokers, after excluding former smokers. Results: The prevalence of current smokers at the time of the diagnosis of sarcoidosis was 59.6% in men and 27.9% in women. With the exception of men in their 30s, the prevalence was higher in all age groups compared with the general Japanese population. The prevalence of lung parenchymal involvement tended to be higher in current smokers than in never‐smokers (odds ratio = 1.33 (0.99–1.77), P = 0.054). Conclusions: This retrospective cohort study suggests that smoking prevalence is higher in Japanese sarcoidosis patients than that reported in Western sarcoidosis patients and that there could be different relationships between smoking and the development of sarcoidosis in these populations. Abstract : We evaluated the prevalence of cigarette smoking in Japanese patients with sarcoidosis. The prevalence of smoking was unexpectedly high compared with the general population. This result suggests that in Japanese subjects, as compared with Western populations, different mechanisms may influence the relationship between smoking and the development of sarcoidosis.