Designing the nanobiointerface of fluorescent nanodiamonds: highly selective targeting of glioma cancer cells. Issue 2 (18th August 2014)

• Record Type: Journal Article
• Authors: Slegerova, Jitka; Hajek, Miroslav; Rehor, Ivan; Sedlak, Frantisek; Stursa, Jan; Hruby, Martin; Cigler, Petr
• Is Part Of: Nanoscale. Volume 7:Issue 2(2015)
• Page Start: 415
• Page End: 420
• Publication Date: 2014-08-18
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c4nr02776k
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Highly effective targeting and background-free, near-infrared imaging of glioma cells was achieved using new nanoparticles based on fluorescent nanodiamonds. The used polymer coating with attached cyclic RGD peptides ensured unusually selective targeting. Abstract : Core–shell nanoparticles based on fluorescent nanodiamonds coated with a biocompatible N -(2-hydroxypropyl)methacrylamide copolymer shell were developed for background-free near-infrared imaging of cancer cells. The particles showed excellent colloidal stability in buffers and culture media. After conjugation with a cyclic RGD peptide they selectively targeted integrin αv β3 receptors on glioblastoma cells with high internalization efficacy.