Supported lipid bilayers as dynamic platforms for tethered particles. Issue 1 (14th November 2014)

• Record Type: Journal Article
• Authors: Hartman, Kevin L.; Kim, Sungi; Kim, Keunsuk; Nam, Jwa-Min
• Is Part Of: Nanoscale. Volume 7:Issue 1(2015)
• Page Start: 66
• Page End: 76
• Publication Date: 2014-11-14
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c4nr05591h
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : We review the tethering strategies for nanoparticle-modified bilayers, as well as the manipulation and applications of these nanoparticle-tethered dynamic platforms. Abstract : Nanoparticle tethering to lipid bilayers enables the observation of hundreds of diffusing particles that are confined within a single field of view. A wide variety of materials ranging from plasmonic metals to soft matter can be stably tethered to the surface of a fluid bilayer by covalent or non-covalent means. The controlled environment of this experimental platform allows direct control over surface compositions and accurate tracking of nanoparticle interactions. This minireview will cover studies that use bilayer-tethered nanoparticles to investigate physical properties related to lipid mobility, biomolecule sensing, and surface interactions, as well as experiments to reversibly manipulate tethered nanoparticles by electric fields.