Gadolinium oxysulfide-coated gold nanorods with improved stability and dual-modal magnetic resonance/photoacoustic imaging contrast enhancement for cancer theranostics. Issue 1 (1st December 2016)

• Record Type: Journal Article
• Authors: Guo, Tao; Lin, Yan; Li, Zhi; Chen, Shan; Huang, Guoming; Lin, Huirong; Wang, Jun; Liu, Gang; Yang, Huang-Hao
• Is Part Of: Nanoscale. Volume 9:Issue 1(2017)
• Page Start: 56
• Page End: 61
• Publication Date: 2016-12-01
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c6nr08281e
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : A gold nanorod@Gd2 O2 S core–shell nanostructure for in vivo dual-modal magnetic resonance and photoacoustic imaging and simultaneous photothermal therapy. Abstract : Gold nanorods (GNRs) are emerging as a promising nanoplatform for cancer theranostics because of their unique optical properties. However, they still suffer from many limitations, such as high cytotoxicity, low thermodynamic and biological stability, and a tedious process for integrating other imaging modalities, for further practical biomedical applications. In this work, a strategy by one-step coating of Gd2 O2 S around GNRs is reported to address these limitations of GNRs. After the coating of the Gd2 O2 S shell, the as-fabricated Gd2 O2 S coated GNRs (GNRs@Gd2 O2 S) show enhanced biocompatibility and photostability, and tunable localized surface plasmon resonance. The strong absorption in the near-infrared region renders GNRs@Gd2 O2 S outstanding photoacoustic imaging and photothermal therapy capabilities. Moreover, owing to the T 1 shortening ability of Gd2 O2 S, the GNRs@Gd2 O2 S also show an excellent T 1 MRI contrast performance. The GNRs@Gd2 O2 S thus can serve as a versatile nanoplatform for cancer theranostics combining dual-modal imaging and photothermal therapy.