Targeted labeling of an early-stage tumor spheroid in a chorioallantoic membrane model with upconversion nanoparticles. Issue 5 (16th December 2014)

• Record Type: Journal Article
• Authors: Liu, Kai; Holz, Jasmin A.; Ding, Yadan; Liu, Xiaomin; Zhang, Youlin; Tu, Langping; Kong, Xianggui; Priem, Bram; Nadort, Annemarie; Lambrechts, Saskia A. G.; Aalders, Maurice C. G.; Buma, Wybren Jan; Liu, Yichun; Zhang, Hong
• Is Part Of: Nanoscale. Volume 7:Issue 5(2015)
• Page Start: 1596
• Page End: 1600
• Publication Date: 2014-12-16
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c4nr05638h
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : In this work target labeling of an early-stage tumor spheroid is realized in a chick embryo CAM model with monoclonal antibody functionalized upconversion NPs. Abstract : In vivo detection of cancer at an early-stage, i.e. smaller than 2 mm, is a challenge in biomedicine. In this work target labeling of an early-stage tumor spheroid (∼500 μm) is realized for the first time in a chick embryo chorioallantoic membrane (CAM) model with monoclonal antibody functionalized upconversion nanoparticles (UCNPs-mAb).