Brief Report: Macrophage Activation in HIV-Infected Adolescent Males Contributes to Differential Bone Loss by Sex. (1st August 2016)

• Record Type: Journal Article
• Authors: Ruan, Alexandra; Tobin, Nicole H.; Mulligan, Kathleen; Rollie, Adrienne; Li, Fan; Sleasman, John; Aldrovandi, Grace M.
• Is Part Of: Journal of acquired immune deficiency syndromes. Volume 72:Number 4(2016)
• Publication Date: 2016-08-01
• Subjects: HIV -- bone -- macrophage activation -- sCD14 -- sVCAM -- IL-6; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome -- Periodicals; AIDS (Disease); Periodicals; 616.9792005
• DOI: 10.1097/QAI.0000000000000953
• Languages: English
• ISSNs: 1525-4135

Abstract

Abstract : Abstract: Accumulating evidence suggests that rates of low bone mass are greater in HIV-infected males than females. Of 11 biomarkers assessed by sex and HIV-status, HIV-infected males had increased levels of soluble CD14 which inversely correlated with bone mineral content and bone mineral density measures, suggesting macrophage activation as a possible mechanism of differential bone loss. Abstract : Supplemental Digital Content is Available in the Text.