Brief Report: HIV Infection Is Associated With Worse Bone Material Properties, Independently of Bone Mineral Density. (1st July 2016)

• Record Type: Journal Article
• Authors: Güerri-Fernández, Robert; Molina, Daniel; Villar-García, Judit; Prieto-Alhambra, Daniel; Mellibovsky, Leonardo; Nogués, Xavier; González-Mena, Alicia; Guelar, Ana; Trenchs-Rodríguez, Marta; Herrera-Fernández, Sabina; Horcajada, Juan Pablo; Díez-Pérez, Adolfo; Knobel, Hernando
• Is Part Of: Journal of acquired immune deficiency syndromes. Volume 72:Number 3(2016)
• Publication Date: 2016-07-01
• Subjects: HIV -- bone material properties -- BMD -- microindentation; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome -- Periodicals; AIDS (Disease); Periodicals; 616.9792005
• DOI: 10.1097/QAI.0000000000000965
• Languages: English
• ISSNs: 1525-4135

Abstract

Abstract : Abstract: Low bone mineral density (BMD) in HIV-infected individuals has been documented in an increasing number of studies. However, it is not clear whether it is the infection itself or the treatment that causes bone impairment. Microindentation measures bone material strength (Bone Material Strength index) directly. We recruited 85 patients, 50 infected with HIV and 35 controls. Median Bone Material Strength index was 84.5 (interquartile range 83–87) in HIV-infected patients and 90 (88.5–93) in controls ( P < 0.001). No significant differences in BMD between cases and controls at any of the sites examined (total hip, femoral neck, and lumbar spine). HIV infection is associated with bone damage, independently of BMD. Abstract : Microindentation is a new technique to assess bone quality. We report significantly worse bone material properties, as measured by microindentation, in treatment-naive patients with HIV than in healthy controls. This deterioration in bone health was not detectable by measuring bone mineral density.