Brief Report: Relationship Among Viral Load Outcomes in HIV Treatment Interruption Trials. (1st July 2016)

• Record Type: Journal Article
• Authors: Treasure, Graham C.; Aga, Evgenia; Bosch, Ronald J.; Mellors, John W.; Kuritzkes, Daniel R.; Para, Michael; Gandhi, Rajesh T.; Li, Jonathan Z.
• Is Part Of: Journal of acquired immune deficiency syndromes. Volume 72:Number 3(2016)
• Publication Date: 2016-07-01
• Subjects: HIV -- treatment interruption -- set point -- viral rebound -- outcome; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome -- Periodicals; AIDS (Disease); Periodicals; 616.9792005
• DOI: 10.1097/QAI.0000000000000964
• Languages: English
• ISSNs: 1525-4135

Abstract

Abstract : Abstract: Viral load (VL) rebound timing and set point were analyzed in 235 participants undergoing analytic treatment interruption (ATI) in 6 AIDS Clinical Trials Group studies. There was no significant association between rebound timing and ATI VL set point for those who rebounded ⩽12 weeks. VL set points were lower in participants with rebound >12 weeks ( P < 0.001) and participants treated during early infection ( P < 0.001). Pre-antiretroviral therapy VL correlated with set point, though 68% of participants had a set point lower than pre-antiretroviral therapy VL. These results illustrate complex relationships between post-ATI virologic outcomes and the potential presence of biological factors mediating rebound timing and set point. Abstract : Supplemental Digital Content is Available in the Text.