Aminoglycoside-based novel probes for bacterial diagnostic and therapeutic applications. Issue 8 (9th December 2016)

• Record Type: Journal Article
• Authors: Zhang, Qingyang; Wang, Qinghua; Xu, Shengnan; Zuo, Limin; You, Xuefu; Hu, Hai-Yu
• Is Part Of: Chemical communications. Volume 53:Issue 8(2017)
• Page Start: 1366
• Page End: 1369
• Publication Date: 2016-12-09
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc08292k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A theranostic agent for broad spectrum pathogenic bacterial imaging and MRSA growth inhibition was developed. Abstract : Specific detection of pathogens has long been recognized as a vital strategy in the control of infectious diseases. Two novel theranostic neomycin analogs exhibit efficient targeting, labelling and killing of broad spectrum bacteria while not damaging macrophage-like cells. Furthermore, lipidated probe2 clearly showed antibacterial activity against methicillin-resistant S. aureus .