Cover Picture: A Dual Topoisomerase Inhibitor of Intense Pro‐Apoptotic and Antileukemic Nature for Cancer Treatment (ChemMedChem 5/2017). (7th March 2017)

• Record Type: Journal Article
• Authors: Meier, Christopher; Steinhauer, Tamara N.; Koczian, Fabian; Plitzko, Birte; Jarolim, Katharina; Girreser, Ulrich; Braig, Simone; Marko, Doris; Vollmar, Angelika M.; Clement, Bernd
• Is Part Of: ChemMedChem. Volume 12:Number 5(2017)
• Page Start: 346
• Page End: 346
• Publication Date: 2017-03-07
• Subjects: antitumor agents -- apoptosis -- heterocycles -- ring closure -- topoisomerase inhibitors; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.201700117
• Languages: English
• ISSNs: 1860-7179

Abstract

Abstract : The front cover picture shows how the human topoisomerase DNA unwinding activities are effectively blocked byP8‐D6, a small molecule designed at the Institute of Pharmaceutical Chemistry of Kiel, Germany. The presence of low nanomolar concentrations ofP8‐D6 initiates programmed cell death in a multitude of human tumor types, especially leukemia cells. Moreover, a simple four‐step synthesis, advantageous drugability properties, and the first in vivo data enable extended drug development options in the field of classic antineoplastic therapy or related modern techniques e.g., antibody–drug conjugates (ADCs). More information can be found in the Communication by Bernd Clement et al. onpage 347 in Issue 5, 2017 (DOI:10.1002/cmdc.201700026 ).