Circadian Disruption: comparing humans with mice. (October 2013)

• Record Type: Journal Article
• Authors: Radetsky, Leora C.; Rea, Mark S.; Bierman, Andrew; Figueiro, Mariana G.
• Is Part Of: Chronobiology international. Volume 30:Number 8(2013)
• Page Start: 1066
• Page End: 1071
• Publication Date: 2013-10
• Subjects: Animal models -- circadian disruption -- ecological measurements -- shiftwork; Chronobiology -- Periodicals; Biological rhythms -- Periodicals; Circadian rhythms -- Periodicals; 571.77
• DOI: 10.3109/07420528.2013.797428
• Languages: English
• ISSNs: 0742-0528

Abstract

Abstract : Disruption of the 24-h light-dark cycle has been implicated as an endocrine disruptor and linked to increased morbidity and mortality in animal studies. Previously reported measurements of circadian disruption in day-shift and rotating-shift nurses were compared with new mouse data where the light-dark patterns simulated shiftwork. Phasor magnitudes, a measure of circadian entrainment, were shown to be similar for humans and for mice when exposed to similar patterns of light and dark. Phasor analyses may be a useful method for quantitatively bridging ecological measurements of circadian disruption in human with parametric studies of health outcomes in a mouse model.