A Lewis acid activated reaction of Zn with EtI to promote highly enantioselective alkyne additions to aldehydes. Issue 2 (18th November 2014)
- Record Type:
- Journal Article
- Title:
- A Lewis acid activated reaction of Zn with EtI to promote highly enantioselective alkyne additions to aldehydes. Issue 2 (18th November 2014)
- Main Title:
- A Lewis acid activated reaction of Zn with EtI to promote highly enantioselective alkyne additions to aldehydes
- Authors:
- Chen, Shan-yong
Liu, Winnie
Wu, Xuedan
Ying, Jun
Yu, Xiaoqi
Pu, Lin - Abstract:
- Abstract : Zn powder and EtI in the presence of ( S )-BINOL and Ti(O i Pr)4 promote highly enantioselective alkyne addition to aldehydes at rt to generate chiral propargylic alcohols. Abstract : An easily available BINOL–Ti(O i Pr)4 catalyst system is found to activate the reaction of Zn powder with EtI for the asymmetric alkyne addition to aldehydes at room temperature. It allows the synthesis of a number of synthetically useful chiral propargylic alcohols with both high yields and high enantioselectivity (up to >96% ee).
- Is Part Of:
- Chemical communications. Volume 51:Issue 2(2015)
- Journal:
- Chemical communications
- Issue:
- Volume 51:Issue 2(2015)
- Issue Display:
- Volume 51, Issue 2 (2015)
- Year:
- 2015
- Volume:
- 51
- Issue:
- 2
- Issue Sort Value:
- 2015-0051-0002-0000
- Page Start:
- 358
- Page End:
- 361
- Publication Date:
- 2014-11-18
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c4cc08031a ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 1376.xml