Antibacterial and anticancer activity of loaded quinazolinone polypyrrole/chitosan silver chloride nanocomposite. Issue 6 (13th April 2017)

• Record Type: Journal Article
• Authors: Salahuddin, Nehal; Elbarbary, Ahmed A.; Alkabes, Hend A.
• Is Part Of: International journal of polymeric materials. Volume 66:Issue 6(2017)
• Page Start: 307
• Page End: 316
• Publication Date: 2017-04-13
• Subjects: Conducting polymers -- polypyrrole chitosan -- polypyrrole chitosan silver chloride -- quinazolinone and anticancer activity; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2016.1201831
• Languages: English
• ISSNs: 0091-4037

Abstract

ABSTRACT: Polypyrrole/chitosan-silver chloride core shell nanocomposite (AgCl@PPC) was prepared by in situ oxidative polymerization of pyrrole (Py) using ferric chloride in the presence of chitosan (CS) and silver nitrate to develop a carrier and controlled release system for 3-amino-2-phenyl-4(3H)-quinazolinone (I). For sake of comparison, polypyrrole chitosan core shell nanoparticles (PPC) were prepared and loaded by (I). Fourier transform infrared spectroscopy, X-ray diffraction and thermal gravimetric analysis confirm that I was loaded into PPC and AgCl@PPC core shell nanocomposites respectively, through physical interaction. Results revealed that loaded AgCl@PPC and PPC exhibited excellent antibacterial and anticancer efficacy against Ehrlich ascites carcinoma cells. GRAPHICAL ABSTRACT: