Impairment and disability in 20 CIDP patients according to disease activity status. Issue 3 (12th September 2013)

• Record Type: Journal Article
• Authors: Panaite, Petrica‐Adrian; Renaud, Susanne; Kraftsik, Rudolf; Steck, Andreas J.; Kuntzer, Thierry
• Is Part Of: Journal of the peripheral nervous system. Volume 18:Issue 3(2013)
• Page Start: 241
• Page End: 246
• Publication Date: 2013-09-12
• Subjects: CDAS -- CIDP -- grading systems -- R‐ODS -- scores; Nervous system -- Periodicals; Nerves, Peripheral -- Diseases -- Periodicals; Peripheral Nervous System Diseases -- Periodicals; Peripheral Nervous System -- Periodicals; 612.81
• DOI: 10.1111/jns5.12038
• Languages: English
• ISSNs: 1085-9489

Abstract

Abstract: Twenty patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) meeting the EFNS/PNS criteria were examined in order to assess differences/similarities between the various grading systems according to CIDP disease activity status (CDAS). A principal component (PC) analysis and the correlations between the following scores were performed: Neurological Symptom Score; MRC sum score; Neurological Impairment Score; Hammersmith Functional Motor Scale; Inflammatory Neuropathy Cause and Treatment (INCAT) Sensory Sum Score; Overall Disability Sum Score; INCAT Disability Score; Rasch‐built Overall Disability Scale. Our analysis outlined two main sets of scales, with high influence in the top two PCs. The first PC that best explained the variability within the cohort consisted of CDAS, general disability scores and motor scores; these parameters were also strongly correlated amongst each other. The second PC explained less the variability and consisted mainly of sensory scores and disease duration; these parameters did not correlate with the scores of the first PC or with the CDAS. Our findings suggest separating screening for motor and sensory deficits when evaluating CIDP patients, as only the motor scores correlate with CDAS.