Genetic variants in the plasminogen activator inhibitor‐1 gene are associated with an increased risk of radiation pneumonitis in lung cancer patients. (17th February 2017)

• Record Type: Journal Article
• Authors: Liu, Bo; Tang, Yang; Yi, Minxiao; Liu, Qingxu; Xiong, Huihua; Hu, Guangyuan; Yuan, Xianglin
• Is Part Of: Cancer medicine. Volume 6:Number 3(2017:Mar.)
• Page Start: 681
• Page End: 688
• Publication Date: 2017-02-17
• Subjects: Lung cancer -- PAI‐1 -- Radiation pneumonitis -- Radiotherapy -- Single‐nucleotide polymorphism; 616.994005
• DOI: 10.1002/cam4.1011
• Languages: English
• ISSNs: 2045-7634

Abstract

Abstract: Plasminogen activator inhibitor‐1 (PAI‐1) plays a crucial role in the process of lung injury, although its association with radiation pneumonitis (RP) is unclear. We hypothesized that genetic variants in PAI‐1 may influence the risk of RP. In this study, 169 lung cancer patients were genotyped for six single‐nucleotide polymorphisms in PAI‐1 using the Sequenom MassARRAY system. The risk of RP was evaluated by Cox proportional hazards analyses. The cumulative RP probabilities by genotype were assessed using Kaplan–Meier analyses. Univariate and multivariate analyses revealed that PAI‐1 :rs7242 GT/GG was correlated with an increased occurrence of grade ≥3 RP (crude hazard ratio = 3.331; 95% confidence interval, 1.168–9.497; P = 0.024). Our results indicated that PAI‐1 :rs7242 in the 3′‐untranslated region of PAI‐1 can be a predictor of grade ≥3 RP before radiotherapy. Abstract : We examined whether genetic variations in PAI‐1 gene is associated with risk of radiation pneumonitis. A cohort of 169 lung cancer patients with radiotherapy were included in this prospective study (NCT02490319) and genotyped by MassArray. We found an association between the presence of rs7242 in 3′‐ untranslated region (UTR) of PAI‐1 gene and occurrence of grade ≥ 3 radiation pneumonitis (RP).