An ultrasensitive electrochemical immunosensor based on the synergistic effect of quaternary Cu2SnZnS4 NCs and cyclodextrin-functionalized graphene. Issue 5 (30th January 2017)

• Record Type: Journal Article
• Authors: Liu, Lei; Zhang, Yihe; Du, Ruifeng; Li, Jinhong; Yu, Xuelian
• Is Part Of: Analyst. Volume 142:Issue 5(2017)
• Page Start: 780
• Page End: 786
• Publication Date: 2017-01-30
• Subjects: Chemistry, Analytic -- Periodicals; 543
• DOI: 10.1039/c6an02538b
• Languages: English
• ISSNs: 0003-2654

Abstract

Abstract : Cu2 ZnSnS4 nanocrystals were first used as electrocatalysts for H2 O2 reduction for the ultrasensitive detection of alpha-fetoprotein. Abstract : In this study, highly monodispersed Cu2 SnZnS4 NCs with a quasi-spherical structure were prepared to construct a sandwich-type electrochemical immunosensor for alpha-fetoprotein detection. Quaternary Cu2 SnZnS4 NCs as novel biomimetic catalysts show an efficient intrinsic peroxidase-like activity for H2 O2 reduction. This excellent catalytic activity is ascribed to the higher electroconductivity than those of the binary Cu2 S and ternary Cu2 SnS3 NCs. Moreover, β-cyclodextrin-functionalized graphene sheets are used as substrate materials that can capture large amounts of primary antibodies due to host–guest interaction and high surface area. Under the optimized conditions, the electrochemical immunosensor exhibites a wide working range from 0.5 pg mL −1 to 10 ng mL −1 and a detection limit of 0.16 pg mL −1 at a signal-to-noise ratio of 3. Good sensitivity, reproducibility, and stability demonstrate its potential application in clinical diagnostics.