Albumin nanoparticle encapsulation of potent cytotoxic therapeutics shows sustained drug release and alleviates cancer drug toxicity. Issue 17 (14th February 2017)
- Record Type:
- Journal Article
- Title:
- Albumin nanoparticle encapsulation of potent cytotoxic therapeutics shows sustained drug release and alleviates cancer drug toxicity. Issue 17 (14th February 2017)
- Main Title:
- Albumin nanoparticle encapsulation of potent cytotoxic therapeutics shows sustained drug release and alleviates cancer drug toxicity
- Authors:
- Wang, Hangxiang
Wu, Jiaping
Xu, Li
Xie, Ke
Chen, Chao
Dong, Yuehan - Abstract:
- Abstract : We present novel HSA-based nanoassemblies for the formulation of highly potent cytotoxic therapeutic drugs such as maytansinoid DM1. Abstract : We here provide the first report on the construction of nanoparticles formulating highly potent cytotoxic therapeutics using albumin. Maytansinoid DM1 can be efficiently integrated into albumin nanoparticles, resulting in remarkable alleviation of in vivo drug toxicity and expanding the repertoire of albumin technology available for cancer therapy.
- Is Part Of:
- Chemical communications. Volume 53:Issue 17(2017)
- Journal:
- Chemical communications
- Issue:
- Volume 53:Issue 17(2017)
- Issue Display:
- Volume 53, Issue 17 (2017)
- Year:
- 2017
- Volume:
- 53
- Issue:
- 17
- Issue Sort Value:
- 2017-0053-0017-0000
- Page Start:
- 2618
- Page End:
- 2621
- Publication Date:
- 2017-02-14
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c6cc08978j ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 2181.xml