Cetirizine derived supramolecular topical gel in action: rational design, characterization and in vivo self-delivery application in treating skin allergy in mice. Issue 32 (24th July 2015)

• Record Type: Journal Article
• Authors: Majumder, Joydeb; Deb, Jolly; Husain, Ahmad; Jana, Siddhartha Sankar; Dastidar, Parthasarathi
• Is Part Of: Journal of materials chemistry. Volume 3:Issue 32(2015)
• Page Start: 6634
• Page End: 6644
• Publication Date: 2015-07-24
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c5tb00676g
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : The easiest reaction like salt formation has been exploited to design the first anti-allergic supramolecular topical gel capable of treating dinitrochlorobenzene (DNCB)-induced skin allergy in mice in a self-delivery fashion. Abstract : A conventional drug delivery system requires a delivery vehicle which often faces various problems such as inefficient drug loading into the delivery vehicle and its release, cytotoxicity and biodegradability of the delivery vehicle, etc., whereas a supramolecular gel based self-delivery system delivers a gelator drug at the target site without using any vehicle thereby getting rid of such problems. Here, a simple salt formation strategy has been employed to convert a well known anti-allergic drug (cetirizine) to a supramolecular gelator for the purpose of making a topical gel for in vivo self-delivery applications. The salt of cetirizine and tyramine (salt3 ) displays excellent gelation properties in methylsalicylate/menthol. The gels are characterised by electron microscopy, and table top- and dynamic rheology. The gelator salt3 displays excellent physiological stability in phosphate buffer saline (PBS) and it is biocompatible in mouse macrophage RAW 264.7 and mouse myoblast C2C12 cell lines. A methylsalicylate/menthol topical gel of salt3 is successfully self-delivered in treating the 2, 4-dinitrochlorobenzene (DNCB)-induced allergic skin condition in mice.