The 3, 4-dioxygenated 5-hydroxy-4-aryl-quinolin-2(1H)-one alkaloids. Results of 20 years of research, uncovering a new family of natural products. Issue 12 (22nd September 2016)

• Record Type: Journal Article
• Authors: Simonetti, Sebastian O.; Larghi, Enrique L.; Kaufman, Teodoro S.
• Is Part Of: Natural product reports. Volume 33:Issue 12(2016:Dec.)
• Page Start: 1425
• Page End: 1446
• Publication Date: 2016-09-22
• Subjects: Natural products -- Periodicals; Produits naturels -- Périodiques; 547.7
• DOI: 10.1039/c6np00064a
• Languages: English
• ISSNs: 0265-0568

Abstract

Abstract : The title alkaloids are discussed. Emphasis is placed on their isolation, source microorganisms and structure, as well as relevant biological activities and synthetic progress. Abstract : Covering: up to April 2016 Aspergillus and Penicillium are fungal species known to produce a high diversity of secondary metabolites, many of them endowed with interesting bioactivity. The small but steadily growing family of the naturally occurring 5-hydroxy-4-aryl-quinolin-2(1 H )-one alkaloids and closely related compounds, which represent the results of various research projects that spanned over 20 years and involved scientists from different continents, are covered here. Emphasis is placed on the isolation and chemical structures of the different compounds, together with their source microorganisms, environmental conditions, country or region of origin, and relevant biological activities. In addition, stereochemical aspects, as well as the proposed biosynthetic pathways for the different members, and the incipient synthetic efforts towards some of the compounds or their key intermediates, are discussed in detail.