An antithrombotic hydrogel with thrombin-responsive fibrinolytic activity: breaking down the clot as it forms. Issue 6 (2nd September 2016)

• Record Type: Journal Article
• Authors: Du, Hui; Li, Cong; Luan, Yafei; Liu, Qi; Yang, Weikang; Yu, Qian; Li, Dan; Brash, John L.; Chen, Hong
• Is Part Of: Materials horizons. Volume 3:Issue 6(2016:Nov.)
• Page Start: 556
• Page End: 562
• Publication Date: 2016-09-02
• Subjects: Materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c6mh00307a
• Languages: English
• ISSNs: 2051-6347

Abstract

Abstract : A novel concept of a thrombolytic material whose activity is triggered by the generation of a clot/thrombus is developed. Abstract : A novel concept of a thrombolytic material whose activity is triggered by the generation of a clot/thrombus is developed. The concept is realized using a tissue plasminogen activator (t-PA)-loaded hydrogel crosslinked by a thrombin-cleavable peptide. The hydrogel is shown to release t-PA in serum and dissolve fibrin clots only when thrombin (generated during clot formation) is present.