Correlating blood and urinary concentrations of clobazam doses in Japanese children and adolescents with intractable epilepsy. (3rd October 2016)

• Record Type: Journal Article
• Authors: Iwasaki, Toshiyuki; Nonoda, Yutaka; Ishida, Tomoya; Toki, Taira; Ishii, Masahiro
• Is Part Of: Biomedical chromatography. Volume 31:Number 4(2017:Apr.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-10-03
• Subjects: clobazam -- clobazam/N‐desmethylclobazam ratio -- creatinine coefficient -- N‐desmethylclobazam -- urinary concentration; Chromatographic analysis -- Periodicals; Biology -- Periodicals; Medicine -- Periodicals; Biology -- Periodicals; Chromatography -- methods -- Periodicals; Medicine -- Periodicals; 543.089
• DOI: 10.1002/bmc.3848
• Languages: English
• ISSNs: 0269-3879

Abstract

Abstract: Clobazam (CLB) is an antiepileptic drug that is metabolized to the major metabolite N ‐desmethylclobazam ( N ‐CLB). Our aim was to evaluate the utility of corrected urinary concentrations of CLB and N ‐CLB in Japanese children and adolescents with epilepsy. Blood and urinary concentrations of CLB and N ‐CLB were evaluated in 42 patients. The urinary and peak blood concentrations were measured 2–3 h after the last dose. The ratio of the blood and urinary creatinine concentrations was used to calculate the corrected urinary concentrations. A moderate correlation was found between the CLB dose and the CLB serum concentration, but this correlation was not found for N ‐CLB. Patients were dichotomized based on two regression lines, which were detected by statistical analyses with a cumulative distribution function: the lower ratio group (CLB/ N ‐CLB < 0.275) and the higher ratio group (≥0.275). Moderate correlations were observed between the CLB dose and the serum concentration or the corrected value of CLB for the lower ratio group, and moderate to strong correlations were observed for the higher ratio group. The corrected urinary concentration of CLB correlates to the CLB dose when stratified by the CLB/ N ‐CLB ratio and may prove practical for clinical estimation of the CLB serum concentration.