Non‐HDL cholesterol vs. Apo B for risk of coronary heart disease in healthy individuals: the EPIC‐Norfolk prospective population study. (17th July 2013)

• Record Type: Journal Article
• Authors: Sondermeijer, Brigitte M.; Rana, Jamal S.; Arsenault, Benoit J.; Shah, Prediman K.; Kastelein, John J.P.; Wareham, Nicholas J.; Boekholdt, S. Matthijs; Khaw, Kay‐Tee
• Is Part Of: European journal of clinical investigation. Volume 43:Number 10(2013:Oct.)
• Page Start: 1009
• Page End: 1015
• Publication Date: 2013-07-17
• Subjects: Apolipoprotein B -- coronary heart disease -- low‐density lipoprotein cholesterol -- non–high‐density lipoprotein cholesterol; Pathology -- Periodicals; Medical research -- Periodicals; 616.075
• DOI: 10.1111/eci.12129
• Languages: English
• ISSNs: 0014-2972

Abstract

Abstract: Background: There is an ongoing debate about the performance of non–high‐density lipoprotein cholesterol (non‐HDL‐C) compared with apolipoprotein B (apo B) in the prediction of coronary heart disease (CHD) risk. Therefore, we compared the associations between non‐HDL‐C and apo B in regard to CHD among apparently healthy Western European individuals. Design: In the European Prospective Investigation into Cancer and Nutrition (EPIC)‐Norfolk prospective population study, 25 639 men and women aged 45–79 years were followed for 11·4 ± 2·8 years. Those with diabetes or prevalent CHD at baseline were excluded. A total of 2066 (12·1%) participants developed CHD during 195 692 person‐years follow‐up. Results: The multivariable‐adjusted hazard ratio [HR] of future CHD per one standard deviation increase was 1·22 [95% confidence interval (CI): 1·17–1·27] for LDL‐C, 1·26 (95% CI 1·20–1·31) for non‐HDL‐C and 1·19 (95% CI 1·14–1·24) for apo B, respectively. The multivariable‐adjusted HR of future CHD in the highest quartile LDL‐C was 1·67 (95% CI: 1·47–1·91). For non‐HDL‐C and apo B, these respective HRs were 1·87 (95% CI: 1·62–2·15) and 1·56 (95% CI: 1·36–1·78). Kaplan–Meier survival analyses showed that there was incremental and comparable increase in risk of CHD with increasing quartiles of both non‐HDL‐C and apo B. Conclusions: In this prospective study, non‐HDL‐C and apo B were comparable in their ability to predict risk of future CHD.