Anti-obesity and lipid lowering effects of Cymodocea nodosa sulphated polysaccharide on high cholesterol-fed-rats. (20th October 2015)

• Record Type: Journal Article
• Authors: Ben Abdallah Kolsi, Rihab; Ben Gara, Amel; Chaaben, Rim; El Feki, Abdelfattah; Paolo Patti, Francesco; El Feki, Lotfi; Belghith, Karima
• Is Part Of: Archives of physiology and biochemistry. Volume 121:Number 5(2015)
• Page Start: 210
• Page End: 217
• Publication Date: 2015-10-20
• Subjects: Polysaccharide -- obesity -- liver-kidney functions; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.3109/13813455.2015.1105266
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: This study aims to evaluate for the first time the effects of Cymodocea nodosa sulphated polysaccharide (CNSP) on lipase activity in vitro and in vivo to high fat diet (HFD)-rats on body weight, lipid profile and liver-kidney functions. The administration of CNSP decreases the body weight and inhibits lipase activity of obese rats in serum and intestine as compared with untreated HDF-rats. This decrease in lipase activity leads to lipid regulation shown by the decrease of total cholesterol (T-Ch), triglycerides (TG) and low density lipoprotein cholesterol (LDL-C) and an increase in high density lipoprotein cholesterol (HDL-C) levels in HFD-rats. Additionally, CNSP administration to HFD-rats induces anti-oxidant activity observed by the increase of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) activities and the decrease in Thiobarbituric acid reactive substances (TBARS) levels and protects liver-kidney functions proven by a decrease in the levels of toxicity parameters in blood.