Metal-free 18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C–H activation. Issue 1 (5th December 2016)

• Record Type: Journal Article
• Authors: Yuan, Gengyang; Wang, Feng; Stephenson, Nickeisha A.; Wang, Lu; Rotstein, Benjamin H.; Vasdev, Neil; Tang, Pingping; Liang, Steven H.
• Is Part Of: Chemical communications. Volume 53:Issue 1(2017)
• Page Start: 126
• Page End: 129
• Publication Date: 2016-12-05
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc07913j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A metal-free and selective method to form [ 18 F]aryl-CF2 H through nucleophilic radiofluorination of benzyl (pseudo)halides and oxidative C–H activation of benzylic C–H bonds has been developed. Abstract : A metal-free and selective method to form [ 18 F]aryl-CF2 H through nucleophilic radiofluorination of benzyl (pseudo)halides and oxidative C–H activation of benzylic C–H bonds has been developed. The method is operationally simple and tolerates a variety of electron-neutral/deficient arenes and heteroarenes.