A longitudinal study on cardiac effects of deconditioning and physical reconditioning using the anterior cruciate ligament injury as a model. (29th April 2013)

• Record Type: Journal Article
• Authors: Steding‐Ehrenborg, Katarina; Hedén, Bo; Herbertsson, Pär; Arheden, Håkan
• Is Part Of: Clinical physiology and functional imaging. Volume 33:Number 6(2013:Nov.)
• Page Start: 423
• Page End: 430
• Publication Date: 2013-04-29
• Subjects: athletes -- left ventricle -- physiology -- total heart volume; Physiology, Pathological -- Periodicals; Diagnostic imaging -- Periodicals; 612
• DOI: 10.1111/cpf.12048
• Languages: English
• ISSNs: 1475-0961

Abstract

Summary: Background: Studies of cardiovascular deconditioning are primarily carried out after experimental bed rest. No previous study has followed the cardiovascular effects of decreased and resumed physical activity in athletes after acute physical injury and convalescence. Anterior cruciate ligament (ACL) injury causes a significantly decreased activity level over a long period, making it an ideal model for studying effects of deconditioning and reconditioning. Therefore, the aim of this study was to investigate how cardiac dimensions and maximal exercise capacity change after an ACL‐injury. Method: Seventeen athletes (5 women) were included. Cardiac magnetic resonance (CMR) was performed within 5 days of the injury (CMR1), before endurance training was resumed (CMR2) and 6 months after the second scan (CMR3). Maximal exercise testing was performed on the same day as CMR2 and 3. Results: The deconditioning phase between CMR1 and CMR2 was 59 ± 28 days. Total heart volume (THV) decreased with −3·1 ± 6·7%, P = 0·056. Between CMR2 and 3 (reconditioning), THV increased significantly (2·5 ± 4·6%, P <0·05). Left and right ventricular EDV decreased during deconditioning (−3·0 ± 5·6% and −4·7 ± 6·6%) and increased during reconditioning (1·7 ± 3·9% and 2·6 ± 6·2%) however not statistically significant. Left ventricular mass (LVM) remained unchanged. VO2 peak (mlmin −1 kg −1 ) increased significantly during the reconditioning phase (6·1 ± 5·3%, P <0·001). Conclusion: Physiological cardiac adaptation to deconditioning and reconditioning caused by severe knee injury with maintained normal daily living during convalescence was smaller than previously shown in bed rest studies. Total heart volume and VO2 peak were significantly affected by reconditioning whilst LVEDV, RVEDV and LVM remained unchanged over the study period.