Sprayable peptide-modified silver nanoparticles as a barrier against bacterial colonization. Issue 46 (11th November 2016)

• Record Type: Journal Article
• Authors: McLaughlin, Sarah; Ahumada, Manuel; Franco, Walfre; Mah, Thien-Fah; Seymour, Richard; Suuronen, Erik J.; Alarcon, Emilio I.
• Is Part Of: Nanoscale. Volume 8:Issue 46(2016)
• Page Start: 19200
• Page End: 19203
• Publication Date: 2016-11-11
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c6nr07976h
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Nanosilver spray-on formulation provides antimicrobial and antibiofilm protection with non-measurable toxicity for skin cells and no in vivo organ infiltration. Abstract : Sprayable formulations of AgNPs were prepared by exchanging citrate capping agents with LL37-SH peptides. The AgNP@LL37 material was then combined with type I collagen to form a stable film once sprayed. The AgNP@LL37 spray prevented Pseudomonas aeruginosa ( P. aeruginosa ) proliferation and eradicated a P. aeruginosa biofilm, while being non-toxic for human skin fibroblasts embedded within 3D artificial skin constructs. Finally, no silver infiltration was observed after spraying on a full-thickness skin wound in a mouse model.