A highly versatile platform based on geometrically well-defined 3D DNA nanostructures for selective recognition and positioning of multiplex targets. Issue 43 (24th October 2016)

• Record Type: Journal Article
• Authors: Dai, Ziwen; Gao, Qi; Cheung, Man Ching; Leung, Hoi Man; Lau, Terrence Chi Kong; Sleiman, Hanadi F.; Lai, King Wai Chiu; Lo, Pik Kwan
• Is Part Of: Nanoscale. Volume 8:Issue 43(2016)
• Page Start: 18291
• Page End: 18295
• Publication Date: 2016-10-24
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c6nr05411k
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : A versatile system based on aptamer-functionalized DNA nanotubes for multiplex recognition and positioning. Abstract : We develop a versatile recognition system based on 3D triangular-shaped DNA nanotubes by integrating three different aptamer sequences along the three edges. This would allow multiple binding activities to be combined into a single system. The versatility of this nanotube platform can also provide a framework for spatial orientation and positioning of different aptamer-binding ligands in a 'pea-pod' architecture.