Design, facile synthesis, molecular docking, DNA binding, and cytotoxic activity of polythiophene and polythiophene-titanium(IV) phosphate nanocomposite. Issue 5 (24th March 2017)

• Record Type: Journal Article
• Authors: Baig, Umair; Gondal, M. A.; Alam, Md. Fazle; Alam, Mahboob; Wani, Waseem A.; Younus, Hina
• Is Part Of: International journal of polymeric materials. Volume 66:Issue 5(2017)
• Page Start: 243
• Page End: 257
• Publication Date: 2017-03-24
• Subjects: Cytotoxic activity -- DNA binding -- molecular docking -- polymer -- polymeric nanocomposite -- toxicity; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2016.1201825
• Languages: English
• ISSNs: 0091-4037

Abstract

ABSTRACT: The present article reports the synthesis of polythiophene-titanium(IV) phosphate nanocomposite (PTh-TiP) by a simple in situ titanium(IV) phosphate assisted chemical polymerization of thiophene. The structure and formation of polymer and its nanocomposite was confirmed by FTIR, XRD, FE-SEM, TEM, and TGA techniques. UV-Visible, fluorescence, and circular dichroism spectrophotometry as well as viscometry and DNA melting studies were used to investigate the DNA binding of PTh and PTh-TiP with calf-thymus DNA. The anticancer activities of these materials against MCF-7 and MDA-MB- 231 cancer cells indicated both PTh and PTh-TiP are moderately active, with the latter being more active than the former. GRAPHICAL ABSTRACT: