Development of polysaccharide-based membranes incorporating the bioactive compound aloin. Issue 4 (4th March 2017) - Bierhalz, Andréa Cristiane Krause
ABSTRACT: Chitosan-alginate (CA) and chitosan-xanthan (CX) membranes containing aloin were developed for use as wound dressings. The effects of aloin-to-biopolymer ratio on membranes morphology, aspect, liquid uptake, mass loss, mechanical properties, thermal behavior, aloin incorporation efficiency, and release kinetics were analyzed. CA membranes showed higher stability in liquid media and greater elongation at break. CX membranes had more homogeneous microstructure and slightly higher tensile strength. The opacity and color intensity of both formulations increased with aloin incorporation. Maximum aloin incorporation efficiencies were 56.0% and 79.5% in CA and CX membranes, respectively, and slower aloin release was observed for CA membranes. GRAPHICAL ABSTRACT: