Genotoxicity evaluation for single‐walled carbon nanotubes in a battery of in vitro and in vivo assays. Issue 9 (5th July 2012)

• Record Type: Journal Article
• Authors: Ema, Makoto; Imamura, Tadashi; Suzuki, Hiroshi; Kobayashi, Norihiro; Naya, Masato; Nakanishi, Junko
• Is Part Of: Journal of applied toxicology. Volume 33:Issue 9(2013)
• Page Start: 933
• Page End: 939
• Publication Date: 2012-07-05
• Subjects: single‐walled carbon nanotubes -- nanomaterials -- genotoxicity -- bacterial reverse mutation test -- chromosomal aberration test -- micronucleus test; Toxicology -- Periodicals; Industrial toxicology -- Periodicals; Environmentally induced diseases -- Periodicals; Toxicology -- Periodicals; 615.9005
• DOI: 10.1002/jat.2772
• Languages: English
• ISSNs: 0260-437X

Abstract

ABSTRACT: The genotoxicity of single‐walled carbon nanotubes (SWCNTs) was determined using a battery of genotoxicity assays, comprising a bacterial reverse mutation test, an in vitro mammalian chromosomal aberration test and a mammalian erythrocytes micronucleus test. SWCNTs had no mutagenicity in S . typhimurium TA98, TA100, TA1535 or TA1537, or in E . coli WP2 uvrA, in the absence or presence of metabolic activation. SWCNTs did not increase the number of structural or numerical chromosomal aberrations after short‐term or continuous exposure. In the micronucleus test using CD‐1 mice, SWCNTs did not affect the proportion of immature erythrocytes, the total proportion of erythrocytes or the number of micronuclei in immature erythrocytes. SWCNTs appear not to pose a genotoxic risk. Copyright © 2012 John Wiley & Sons, Ltd. Abstract : Single‐walled carbon nanotubes (SWCNTs) had no mutagenicity in S. typhimurium TA98, TA100, TA1535, or TA1537, or in E. coli WP2uvrA, in the absence or presence of metabolic activation. SWCNTs did not increase the number of structural or numerical chromosomal aberrations after short‐term or continuous exposure. In the micronucleus test using CD‐1 mice, SWCNTs did not affect the proportion of immature erythrocytes, the total proportion of erythrocytes, or the number of micronuclei in immature erythrocytes.