C1q binding is not an independent risk factor for kidney allograft loss after an acute antibody‐mediated rejection episode: a retrospective cohort study. (March 2017)

• Record Type: Journal Article
• Authors: Moktefi, Anissa; Parisot, Juliette; Desvaux, Dominique; Canoui‐Poitrine, Florence; Brocheriou, Isabelle; Peltier, Julie; Audard, Vincent; Kofman, Tomek; Suberbielle, Caroline; Lang, Philippe; Rondeau, Eric; Grimbert, Philippe; Matignon, Marie
• Is Part Of: Transplant international. Volume 30:Number 3(2017)
• Page Start: 277
• Page End: 287
• Publication Date: 2017-03
• Subjects: allograft survival -- antibody‐mediated rejection -- C1q‐binding DSA -- C4d staining -- kidney transplantation; Transplantation of organs, tissues, etc -- Periodicals; 617.95405
• DOI: 10.1111/tri.12905
• Languages: English
• ISSNs: 0934-0874

Abstract

Summary: After kidney transplantation, C4d is an incomplete marker of acute antibody‐mediated rejection (AMR) and C1q‐binding donor‐specific antibodies (DSA) have been associated with allograft survival. However, the impact on allograft survival of C1q+ DSA after clinical AMR has not been studied yet. We analysed retrospectively in clinical AMR C4d staining and C1q‐binding impact on allograft survival. We compared clinical, histological and serological features of C4d− and C4d+ AMR, C1q+ and C1q− DSA AMR and analysed C4d and C1q‐binding impact on allograft survival. Among 500 for‐cause kidney allograft biopsies, 48 fulfilled AMR criteria. C4d+ AMR [ N = 18 (37.5%)] have significantly higher number class I DSA ( P = 0.02), higher microvascular score ( P = 0.02) and more transplant glomerulopathy ( P = 0.04). C1q+ AMR [ N = 20 (44%)] presented with significantly more class I and class II DSA ( P = 0.005 and 0.04) and C4d+ staining ( P = 0.01). Graft losses were significantly higher in the C4d+ group ( P = 0.04) but similar in C1q groups. C4d+ but not C1q+ binding was an independent risk factor for graft loss [HR = 2.65; (1.11–6.34); P = 0.028]. In our cohort of clinical AMR, C4d+ staining but not C1q+ binding is an independent risk factor for graft loss. Allograft loss and patient survival were similar in C1q+ and C1q− AMR.