In vitro efficacy of a novel potassium oxalate hydrogel for dentin hypersensitivity. (1st March 2017)

• Record Type: Journal Article
• Authors: Varoni, Elena M.; Zuccheri, Tommaso; Carletta, Andrea; Palazzo, Barbara; Cochis, Andrea; Colonna, Martino; Rimondini, Lia
• Is Part Of: European journal of oral sciences. Volume 125:Number 2(2017)
• Page Start: 151
• Page End: 159
• Publication Date: 2017-03-01
• Subjects: dentin desensitizing agents -- dentinal fluid -- tooth remineralization; Dentistry -- Periodicals; Oral medicine -- Periodicals; 617.6005
• DOI: 10.1111/eos.12334
• Languages: English
• ISSNs: 0909-8836

Abstract

Abstract : A novel potassium oxalate‐based hydrogel is proposed for treating dentin hypersensitivity and this study evaluates its in vitro performance as a remineralizing, desensitizing agent. Etched disks of human dentin were treated for 10 or 20 min using the test hydrogel, to mimic a professional application with dental mouth guards. Dentin disks were evaluated in terms of permeability indexes in a fluid‐filled system, the surface morphology was assessed by scanning electron microscopy, and the structural properties were studied using X‐ray diffraction analysis. The potassium oxalate hydrogel significantly reduced dentin permeability, in a time‐dependent manner, and occluded most of the patent dentinal tubules via crystal precipitation, forming a remineralized layer. After hydrogel treatments, an acid solution (pH 4.2) was applied to the disks for 30 s, or 1, 2, or 5 min, in order to reproduce a plaque‐like oral acidity, and further analysis showed a good resistance of the remineralized layer to the acid challenge. The potassium oxalate‐based hydrogel showed a better performance over commercially available products and artificial saliva, appearing a promising candidate for the treatment of dentin hypersensitivity.