Osteoblast response to the surface topography of hydroxyapatite two‐dimensional films. Issue 4 (23rd January 2017)

• Record Type: Journal Article
• Authors: Yang, Gai; Liu, Zili; Guo, Yuming; Zhang, Jie; Li, Han; Shi, Weike; Feng, Jing; Wang, Kui; Yang, Lin
• Is Part Of: Journal of biomedical materials research. Volume 105:Issue 4(2017)
• Page Start: 991
• Page End: 999
• Publication Date: 2017-01-23
• Subjects: hydroxyapatite -- two‐dimensional films -- roughness -- osteoblast -- cellular response; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.a.35967
• Languages: English
• ISSNs: 1549-3296

Abstract

Abstract: In the current study, three hydroxyapatite two‐dimensional films with similar wettability but different topological roughness have been prepared through a facile one‐step method using hydrated polylactic acid discs as substrates. The results indicated that the protein adsorption capabilities of the hydroxyapatite two‐dimensional films and the proliferation of osteoblast cells on the as‐prepared films increased obviously with the increase of the films' roughness. These reveal that the cellular responses to two‐dimensional materials can be efficiently tuned by easily adjusting the topological roughness. This finding affords an efficient strategy to regulate the cellular response to bioinorganic two‐dimensional materials and significantly expanded their application potentials in tissue engineering. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 991–999, 2017.