Exosomes participate in the carcinogenesis and the malignant behavior of gastric cancer. (4th May 2017)

• Record Type: Journal Article
• Authors: Yan, Yunmeng; Fu, Guangzhen; Ye, Yafei; Ming, Liang
• Is Part Of: Scandinavian journal of gastroenterology. Volume 52:Number 5(2017)
• Page Start: 499
• Page End: 504
• Publication Date: 2017-05-04
• Subjects: Exosomes -- gastric cancer -- invasion -- metastasis -- chemotherapy; Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; 616.33
• DOI: 10.1080/00365521.2016.1278458
• Languages: English
• ISSNs: 0036-5521

Abstract

Abstract: Objective : In order to summarize the role of exosomes in invasion and metastasis in gastric cancer (GC). Material : Exosomes are vesicles of endocytic origin ranging from 30 to 100 nm in size; they are composed of a lipid bilayer and contain DNA, mRNA, miRNA, circular RNA and multiple proteins. Recently, increasing evidence shows that exosomes play a crucial role in the tumorigenesis of GC. Results : In this review, we focus on the latest findings on GC exosomes, mainly summarizing their role in invasion and metastasis in GC. Then, exosomes? potential functions as novel diagnostic and therapeutic biomarkers for GC are briefly discussed. At last, we prospect the clinical application perspective of exosomes in GC. Conclusions : Exosomes play a vital role in gastric cancer carcinogenesis and metastasis.