Combining Organocatalysis and Lanthanide Catalysis: A Sequential One‐Pot Quadruple Reaction Sequence/Hetero‐Diels–Alder Asymmetric Synthesis of Functionalized Tricycles. (23rd November 2016)

• Record Type: Journal Article
• Authors: Dochain, Simon; Vetica, Fabrizio; Puttreddy, Rakesh; Rissanen, Kari; Enders, Dieter
• Is Part Of: Angewandte Chemie. Volume 128:Number 52(2016)
• Page Start: 16387
• Page End: 16389
• Publication Date: 2016-11-23
• Subjects: Asymmetrische Katalyse -- Heterocyclen -- Lanthanoiden -- Organokatalyse -- Synthesemethoden; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201610196
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: A stereoselective one‐pot synthesis of functionalized complex tricyclic polyethers has been achieved using the combination of secondary amine and lanthanide catalysis. This one‐pot quadruple reaction/Hetero‐Diels–Alder sequence gave good yields (per step) as well as excellent diastereo‐ and enantioselectivities. Furthermore, the particular combination of lanthanide complexes with organocatalysis is one of the first examples described for sequential catalysis.