Brief Report: HIV-1 Infection Results in Increased Frequency of Active and Inflammatory SlanDCs that Produce High Level of IL-1β. (1st September 2016)

• Record Type: Journal Article
• Authors: Tufa, Dejene M.; Ahmad, Fareed; Chatterjee, Debanjana; Ahrenstorf, Gerrit; Schmidt, Reinhold E.; Jacobs, Roland
• Is Part Of: Journal of acquired immune deficiency syndromes. Volume 73:Number 1(2016)
• Publication Date: 2016-09-01
• Subjects: HIV -- slanDCs -- IL-1β; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome -- Periodicals; AIDS (Disease); Periodicals; 616.9792005
• DOI: 10.1097/QAI.0000000000001082
• Languages: English
• ISSNs: 1525-4135

Abstract

Abstract : Abstract: HIV infection is marked by phenotypic and functional alterations of immune cells. Different studies have shown both numerical and functional deterioration of dendritic cells in HIV-1–infected patients. In this study, we report an increase of inflammatory 6-sulfo LacNAc dendritic cells (slanDCs) that are more activated and produce higher amounts of interleukin (IL)-1β during HIV-1 infection as compared with healthy controls. IL-1β plays a regulatory role in chronic inflammatory disorders. Therefore, our findings might reveal a compensatory regulatory function of slanDCs during HIV-1 infection. Abstract : Supplemental Digital Content is Available in the Text.