Spitting out the demons: Extracellular vesicles in glioblastoma. Issue 2 (4th March 2017)

• Record Type: Journal Article
• Authors: André-Grégoire, Gwennan; Gavard, Julie
• Is Part Of: Cell adhesion & migration. Volume 11:Issue 2(2017)
• Page Start: 164
• Page End: 172
• Publication Date: 2017-03-04
• Subjects: angiogenesis -- brain tumors -- exosomes -- glioma -- permeability -- signaling -- tumor microenvironment; Cell adhesion -- Periodicals; Cell migration -- Periodicals; Cell interaction -- Periodicals; 574.876
• DOI: 10.1080/19336918.2016.1247145
• Languages: English
• ISSNs: 1933-6918

Abstract

ABSTRACT: Discovered decades ago, extracellular vesicles (EVs) emerge as dedicated organelles, able to deliver protected, specific cellular cues throughout the organism. While virtually every cell can release EVs, cancer cells co-opted this feature and efficiently unleashed them both in the tumor microenvironment and toward healthy tissues. This might contribute to tumor aggressiveness and spreading. Cancer-derived EVs that contain DNA, mRNA, miRNA, and packed and transmembrane proteins can operate locally or at distance. This review will focus on the high-grade brain tumor (i.e. glioblastoma)-derived EVs, discussing recent reports on i) their phenotype and content, ii) their putative functions, and iii) their clinical potential for improving diagnosis and therapeutics.