Considerations for the design, analysis and presentation of in vivo studies. Issue 3 (March 2017)

• Record Type: Journal Article
• Authors: Ranstam, J.; Cook, J.A.
• Is Part Of: Osteoarthritis and cartilage. Volume 25:Issue 3(2017)
• Page Start: 364
• Page End: 368
• Publication Date: 2017-03
• Subjects: Biostatistics -- Inference -- Results presentation -- Experimental design -- Study protocol -- Analysis plan; Osteoarthritis -- Periodicals; Cartilage -- Periodicals; Osteoarthritis -- Periodicals; Cartilage -- Periodicals; Arthrose -- Périodiques; Articulations -- Maladies -- Périodiques; 616.7223005
• DOI: 10.1016/j.joca.2016.06.023
• Languages: English
• ISSNs: 1063-4584

Abstract

Summary: Objective: To describe, explain and give practical suggestions regarding important principles and key methodological challenges in the study design, statistical analysis, and reporting of results from in vivo studies. Conclusions: Pre-specifying endpoints and analysis, recognizing the common underlying assumption of statistically independent observations, performing sample size calculations, and addressing multiplicity issues are important parts of an in vivo study. A clear reporting of results and informative graphical presentations of data are other important parts.