Application of Lawesson's reagent in the synthesis of sulfur-containing medicinally significant natural alkaloids. (4th March 2017)

• Record Type: Journal Article
• Authors: Larik, Fayaz Ali; Saeed, Aamer; Muqadar, Urooj; Channar, Pervaiz Ali
• Is Part Of: Journal of sulfur chemistry. Volume 38:Number 2(2017)
• Page Start: 206
• Page End: 227
• Publication Date: 2017-03-04
• Subjects: Lawesson's reagent -- thionation -- alkaloids -- natural products -- medicinal value; Sulfur -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.72305
• DOI: 10.1080/17415993.2016.1255743
• Languages: English
• ISSNs: 1741-5993

Abstract

ABSTRACT: This review aims to illustrate the applications of Lawesson's reagent (LR) [2, 4-bis(p-methoxyphenyl)-1, 3, 2, 4-dithiadiphosphetane-2, 4-disulfide] in the synthesis of naturally occurring medicinally important alkaloids. LR is primarily used for thionation; it is a versatile reagent employed for diverse transformations (cyclizations, rearrangements, and synthesis of heterocyclic compounds). The medicinal importance of alkaloids has also been concisely highlighted. The main focus of the review is the use of LR in the synthesis of natural alkaloids and only the thionation steps involved have been highlighted. GRAPHICAL ABSTRACT: