Platycodin D Inhibits Osteoclastogenesis by Repressing the NFATc1 and MAPK Signaling Pathway. Issue 4 (28th November 2016)

• Record Type: Journal Article
• Authors: Choi, Jae Ho; Han, Younho; Kim, Yong An; Jin, Sun Woo; Lee, Gi Ho; Jeong, Hyung Min; Lee, Hyun Sun; Chung, Young Chul; Lee, Young Chun; Kim, Eun Ju; Lee, Kwang Youl; Jeong, Hye Gwang
• Is Part Of: Journal of cellular biochemistry. Volume 118:Issue 4(2017)
• Page Start: 860
• Page End: 868
• Publication Date: 2016-11-28
• Subjects: PLATYCODON GRANDIFLORUM -- SAPONINS -- PLATYCODIN D -- BONE LOSS -- OSTEOCLAST -- OVARIECTOMY; Cytochemistry -- Periodicals; 572
• DOI: 10.1002/jcb.25763
• Languages: English
• ISSNs: 0730-2312

Abstract

ABSTRACT: Platycodon grandiflorum root‐derived saponins (Changkil saponins, CKS) are reported to have many pharmacological activities. In our latest research, CKS was proven to have a significant osteogenic effect. However, the detail molecular mechanism of CKS on osteoclastic differentiation has not been fully investigated. Administration of CKS considerably reduced OVX‐induced bone loss, and ameliorated the reduction in plasma levels of alkaline phosphatase, calcium, and phosphorus observed in OVX mice. CKS also repressed the deterioration of bone trabecular microarchitecture. Interestingly, platycodin D, the most abundant and major pharmacological constituent of triterpenoid CKS, inhibited receptor activator of NF‐κB ligand (RANKL)‐induced activation of NF‐κB, and ERK and p38 MAPK, ultimately repressing osteoclast differentiation. OVX‐induced bone turnover was attenuated by CKS, possibly via repression of osteoclast differentiation by platycodin D, the active component of CKS. Platycodin D can be regarded as an antiosteoporotic candidate for treatment of osteoporosis diseases. J. Cell. Biochem. 118: 860–868, 2017. © 2016 Wiley Periodicals, Inc. Abstract : Platycodon grandiflorum root‐derived saponins (CKS) ameliorated the reduction in the plasma levels of bone formation markers and improved OVX‐induced bone loss. Platycodin D inhibited osteoclast precursors and osteoclast differentiation. Platycodin D reduced RANKL‐induced activation of NF‐κB, ERK, p38 MAPKs, and Akt.