Estimating vaccine effectiveness in preventing laboratory‐confirmed influenza in outpatient settings in South Africa, 2015. Issue 2 (20th December 2016)

• Record Type: Journal Article
• Authors: McAnerney, Johanna M.; Walaza, Sibongile; Tempia, Stefano; Blumberg, Lucille; Treurnicht, Florette K.; Madhi, Shabir A.; Valley‐Omar, Ziyaad; Cohen, Cheryl
• Is Part Of: Influenza and other respiratory viruses. Volume 11:Issue 2(2017)
• Page Start: 177
• Page End: 181
• Publication Date: 2016-12-20
• Subjects: effectiveness -- influenza -- vaccine; Influenza -- Periodicals; Respiratory infections -- Periodicals; Virus diseases -- Periodicals; Influenza, Human -- Periodicals; Respiratory Tract Diseases -- Periodicals; Virus Diseases -- Periodicals; Grippe -- Périodiques; Appareil respiratoire -- Infections -- Périodiques; Maladies à virus -- Périodiques; 616.203
• DOI: 10.1111/irv.12436
• Languages: English
• ISSNs: 1750-2640

Abstract

Abstract : Trivalent seasonal influenza vaccine effectiveness during the 2015 season in South Africa was assessed using a test‐negative case control study design. Influenza A(H1N1)pdm09 was the dominant circulating strain. Overall influenza vaccine coverage was 3.2% (29/899). The vaccine effectiveness estimate, against any influenza virus infection, adjusted for age, underlying conditions and timing within season was 46.2% (95% CI: −23.5 to 76.5), and 53.6% (95% CI: −62.6 to 80.3) against influenza A(H1N1)pdm09.