Chiral Nanoparticle as a New Efficient Antimicrobial Nanoagent. Issue 4 (27th December 2016)

• Record Type: Journal Article
• Authors: Xin, Qi; Liu, Qian; Geng, Lingling; Fang, Qiaojun; Gong, Jian Ru
• Is Part Of: Advanced healthcare materials. Volume 6:Issue 4(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-12-27
• Subjects: antimicrobial -- chirality -- graphene quantum dots -- nanoparticles -- selective toxicity; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201601011
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : d ‐type functionalized nanoparticles (NPs) can bind to MurD ligase with high affinity and inhibit its peptidoglycan synthetic enzyme activity, and finally cause bacterial killing. In contrast, its L‐type counterpart displays a negligible effect, indicating that the chiral structure of the functionalized NPs plays an essential role in their binding interaction with MurD and therefore the antibacterial activity.