In Vivo Ischemia Detection by Luminescent Nanothermometers. Issue 4 (23rd December 2016)

• Record Type: Journal Article
• Authors: Ximendes, Erving Clayton; Rocha, Uéslen; del Rosal, Blanca; Vaquero, Alberto; Sanz‐Rodríguez, Francisco; Monge, Luis; Ren, Fuqiang; Vetrone, Fiorenzo; Ma, Dongling; García‐Solé, José; Jacinto, Carlos; Jaque, Daniel; Fernández, Nuria
• Is Part Of: Advanced healthcare materials. Volume 6:Issue 4(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-12-23
• Subjects: ischemia -- nanoparticles -- nanothermometry -- thermal transients; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201601195
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : There is an urgent need to develop new diagnosis tools for real in vivo detection of first stages of ischemia for the early treatment of cardiovascular diseases and accidents. However, traditional approaches show low sensitivity and a limited penetration into tissues, so they are only applicable for the detection of surface lesions. Here, it is shown how the superior thermal sensing capabilities of near infrared‐emitting quantum dots (NIR‐QDs) can be efficiently used for in vivo detection of subcutaneous ischemic tissues. In particular, NIR‐QDs make possible ischemia detection by high penetration transient thermometry studies in a murine ischemic hindlimb model. NIR‐QDs nanothermometers are able to identify ischemic tissues by means of their faster thermal dynamics. In addition, they have shown to be capable of monitoring both the revascularization and damage recovery processes of ischemic tissues. This work demonstrates the applicability of fluorescence nanothermometry for ischemia detection and treatment, as well as a tool for early diagnosis of cardiovascular disease. Abstract : Near Infrared emitting quantum dots are used as deep tissue nanothermometers capable of recording thermal relaxation dynamics in a murine ischemic hindlimb model. Subcutaneous thermal transients have been used to elucidate the presence of ischemia and inflammation processes as well as to monitor damage recovery.