Cancer risk associated single nucleotide polymorphisms of mitochondrial D-loop and 8-hydroxy-2'-deoxyguanosine levels in gastric cancer. Issue 2 (4th March 2017)

• Record Type: Journal Article
• Authors: Wang, Yingnan; Zhao, Yufei; Zhao, Yue; Luo, Xiaoxu; Guo, Zhanjun; Zhang, Ruixing
• Is Part Of: Biotechnology, biotechnological equipment. Volume 31:Issue 2(2017)
• Page Start: 363
• Page End: 366
• Publication Date: 2017-03-04
• Subjects: 8-OHdG -- mtDNA -- D-loop -- SNPs -- gastric cancer; Biotechnology -- Periodicals; Biotechnology -- Periodicals; Biotechnology -- instrumentation -- Periodicals; Periodicals; 660.605
• DOI: 10.1080/13102818.2016.1270173
• Languages: English
• ISSNs: 1310-2818

Abstract

ABSTRACT: The accumulation of mutations and single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) is related to gastric carcinogenesis. To evaluate the potential relationships between DNA damage and D-loop SNPs, we measured the 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in the gastric cancer tissue by immmunostaining. Our data showed that the gastric cancer susceptibility SNP of 16519C was associated with higher 8-OHdG levels. Taken together, the cancer-risk associated D-loop SNPs might initiate carcinogenesis through increasing oxidative damage.