Biosynthesized Gold Nanoclusters and Iron Complexes as Scaffolds for Multimodal Cancer Bioimaging. Issue 45 (27th September 2016)

• Record Type: Journal Article
• Authors: Zhao, Chunqiu; Du, Tianyu; Rehman, Fawad ur; Lai, Lanmei; Liu, Xiaoli; Jiang, Xuerui; Li, Xiaoqi; Chen, Yun; Zhang, Hang; Sun, Yi; Luo, Shouhua; Jiang, Hui; Selke, Matthias; Wang, Xuemei
• Is Part Of: Small. Volume 12:Issue 45(2016)
• Page Start: 6255
• Page End: 6265
• Publication Date: 2016-09-27
• Subjects: biosynthesis -- gold nanoclusters -- iron complexes -- multimodal bioimaging; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201602526
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : Cancer treatment has a far greater chance of success if the neoplasm is diagnosed before the onset of metastasis to vital organs. Hence, cancer early diagnosis is extremely important and remains a major challenge in modern therapeutics. In this contribution, facile and new method for rapid multimodal tumor bioimaging is reported by using biosynthesized iron complexes and gold nanoclusters via simple introduction of AuCl4 − and Fe 2+ ions. The observations demonstrate that the biosynthesized Au nanoclusters may act as fluorescent and computed tomography probes for cancer bioimaging while the iron complexes behave as effective contrast agent for magnetic resonance imaging. The biosynthesized iron complexes and gold nanoclusters are found biocompatible in vitro (MTT (3‐(4, 5‐dimethylthiazol‐2‐yl)‐2, 5‐diphenyltetrazolium bromide) assay) and in vivo for all the vital organs of circulatory and excretory system. These observations raise the possibility that the biosynthesized probes may find applications in future clinical diagnosis for deep seated early neoplasms by multimodal imaging. Abstract : The Au‐Fe ions (AuCl4 − ions (i.e., HAuCl4 ) and Fe 2+ ions (i.e., FeCl2 )) can be converted to Au NCs and iron complexes in the presence of glutathione (GSH). Since the tumor microenvironment is richer in GSH compared with normal cells or tissues, this is encouraging for the use of Au‐Fe ions for target cancer multimodal bioimaging.