Copper-catalyzed one-pot oxidative amidation of alcohol to amide via C–H activation. Issue 92 (20th September 2016)

• Record Type: Journal Article
• Authors: Gu, Jiajia; Fang, Zheng; Yang, Yuhang; Yang, Zhao; Wan, Li; Li, Xin; Wei, Ping; Guo, Kai
• Is Part Of: RSC advances. Volume 6:Issue 92(2016)
• Page Start: 89413
• Page End: 89416
• Publication Date: 2016-09-20
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra20732d
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Copper-catalyzed one-pot oxidative amidation of both aliphatic and aromatic alcohols with N -chloramines, prepared in situ from many types of primary and secondary amines, to form amides under mild conditions. Abstract : A one-pot oxidative amidation of both aliphatic and aromatic alcohols with N -chloramines, prepared in situ from many types of primary and secondary amines, was developed. This cross-coupling reaction integrates alcohol oxidation and amide bond formation, which are usually accomplished separately, into a single operation. And it was green, simple and convenient, which has a wide substrate scope and makes use of cheap, abundant, and easily available reagents. The practical value of this method is highlighted through the synthesis of a high-profile pharmaceutical agent, acetylprocainamide.