C-Reactive Protein in Idiopathic Inflammatory Myopathies. Issue 1 (3rd April 2015)

• Record Type: Journal Article
• Authors: Hanisch, Frank; Zierz, Stephan
• Is Part Of: Myopain. Volume 23:Issue 1/2(2015)
• Page Start: 45
• Page End: 51
• Publication Date: 2015-04-03
• Subjects: C-reacitve protein -- dermatomyositis -- erythrocyte sedimentation rate -- idiopathic inflammatory myopathy -- Jo-1 syndrome -- polymyositis -- sporadic inclusion myositis; Nonarticular rheumatism -- Periodicals; Myalgia -- Periodicals; Musculoskeletal system -- Diseases -- Periodicals; Pain -- Periodicals; Fibromyalgia; Myofascial Pain Syndromes; Musculoskeletal system -- Diseases; Myalgia; Nonarticular rheumatism; Pain; Periodicals; Periodicals; 616.742
• DOI: 10.3109/10582452.2013.852151
• Languages: English
• ISSNs: 2470-8593

Abstract

Abstract: Objectives : To characterize C-reactive protein [CRP] in polymyositis [PM], dermatomyositis [DM], Jo-1 syndrome [Jo-1] and sporadic inclusion body myositis [sIBM]. Methods : C-reactive protein obtained before the start of immunosuppressive therapy was analyzed retrospectively in 61 therapy naïve patients [PM n = 27, DM n = 15, Jo-1 n = 5, sIBM n = 14]. All patients had a diagnosis of idiopathic inflammatory myopathy confirmed by muscle biopsy. Results : C-reactive protein was significantly higher in DM and Jo-1 compared to PM and sIBM [ANOVA p < 0.001]. The CRP levels less than twice the upper limit were found in 79% of sIBM patients, 85% of PM patients, 20% Jo-1 of patients, 53% of DM patients. C-reactive protein showed no correlation with creatine kinase and erythrocyte sedimentation rate. Conclusions : The CRP is elevated in a minority of patients with myositis, mostly associated with interstitial lung disease and malignancies.