Cholecystitis and nephrotic syndrome complicating Epstein–Barr virus primary infection. (2nd January 2017)

• Record Type: Journal Article
• Authors: Rodà, Diana; Huici, Malka; Ricart, Sílvia; Vila, Jordi; Fortuny, Clàudia; Alsina, Laia
• Is Part Of: Paediatrics and international child health. Volume 37:Number 1(2017)
• Page Start: 74
• Page End: 77
• Publication Date: 2017-01-02
• Subjects: Epstein–Barr virus -- Acalculous cholecystitis -- Nephrotic syndrome -- Haemophagocytic lymphohistiocytosis syndrome; Pediatrics -- Developing countries -- Periodicals; Children -- Health and hygiene -- Developing countries -- Periodicals; Children -- Diseases -- Developing countries -- Periodicals; 618.920009172405
• DOI: 10.1080/20469047.2015.1135561
• Languages: English
• ISSNs: 2046-9047

Abstract

Abstract : Epstein–Barr virus (EBV) infection results in a spectrum of clinical manifestations. The host immune response to EBV plays a key role in the extent and degree of clinical features, which in children under 4 years of age are usually mild, non-specific and self-limiting. A 2-year-old boy in whom no known immune disorder could be found presented with acute acalculous cholecystitis, renal dysfunction with massive proteinuria, ascites, pleural effusion, minimal peripheral oedema and a severe systemic inflammatory response. Improvement occurred after initiation of corticosteroids and antiviral treatment with gancyclovir. In severely symptomatic or complicated EBV infection, a primary immunodeficiency must be suspected. If a primary immunodeficiency has been ruled out, the correct management of severe EBV infection in the immunocompetent host remains controversial.