Blood Compatibility of Multilayered Polyelectrolyte Films Containing Immobilized Gold Nanoparticles. (28th October 2016)

• Record Type: Journal Article
• Authors: Pallotta, Arnaud; Parent, Marianne; Clarot, Igor; Luo, Ming; Borr, Vincent; Dan, Pan; Decot, Véronique; Menu, Patrick; Safar, Ramia; Joubert, Olivier; Leroy, Pierre; Boudier, Ariane
• Is Part Of: Particle and particle systems characterization. Volume 34:Number 1(2017:Jan.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-10-28
• Subjects: biocompatibility -- gold nanoparticles -- layer‐by‐layer films -- nanostructured material -- stability; Particles -- Periodicals; 620.43
• DOI: 10.1002/ppsc.201600184
• Languages: English
• ISSNs: 0934-0866

Abstract

Abstract : Surface material functionalization including layer‐by‐layer (LbL) polyelectrolyte films with incorporated nanoparticles is a growing field with a wide range of biomedical applications: drug reservoirs, medical devices, or tissue engineering. In parallel, gold nanoparticles (AuNPs) can be grafted by drugs and sensitive molecules using simple protocols. This study shows that AuNP behavior is modified when they are entrapped into three partner LbL films in comparison to the colloidal solution. A polycationic (polyallylamine hydrochloride (PAH)) and a polyanionic (polyacrylic acid (PAA)) polymer is used to build films based on three cycles ((PAH/AuNP/PAA)3 ). To investigate the interaction with biomolecules and cells, three different films are developed changing the outer layer (either PAH or AuNP or PAA) with the same number of AuNP deposit. The best biocompatibility is observed with a polyacrylic acid outer layer. Due to the high capacity of drug grafting on gold nanoparticles, the results seem promising for the development of nanostructured biomedical devices. Abstract : Gold nanoparticle stability is enhanced when they are entrapped into three partner layer‐by‐layer polyelectrolyte films compared to the colloidal solution. The best biocompatibility regarding various biological materials is observed when a polyacrylic acid is present at the outer layer. Due to the high capacity of drug grafting on gold nanoparticles, the results seem promising for the development of nanostructured biomedical devices.